Search results for "Spontaneous reporting"

showing 2 items of 2 documents

Are the Adverse Drug Reactions of Amoxycillin and Amoxycillin-Clavulanic Acid Similar?

1996

UNLABELLED In an attempt to assess the relative toxicity of amoxycillin and amoxycillin-clavulanic acid, we compared the adverse drug reactions reports collected using the spontaneous reporting system of a Regional Drug Surveillance Centre of Spain for both drugs between November 1986 and December 1992. During the 7-year period 1986-92, the 247 reports of amoxycillin-clavulanic acid represent twice the number of reports of amoxycillin alone, and the number of reports related with sales received concerning the association were higher than those concerning amoxycillin alone. The adverse effects classified as severe were quantitatively and qualitatively similar for both drugs and gastrointesti…

Drugmedicine.medical_specialtyRelative toxicityEpidemiologybusiness.industrymedia_common.quotation_subjectAmoxycillin-Clavulanic AcidPharmacologyReporting rateInternal medicineSpontaneous reportingpolycyclic compoundsmedicinePharmacology (medical)Drug reactionAdverse effectbusinessmedia_commonPharmacoepidemiology and Drug Safety
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Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.

2006

Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …

DrugAdultMalemedicine.medical_specialtyAdolescentmedia_common.quotation_subjectPharmacology toxicologyToxicologyDrugdexDrug PrescriptionsInternal medicineEpidemiologymedicineHumansPharmacology (medical)Drug InteractionsSummary of Product CharacteristicsRisk factorMedical prescriptiondrug information sourcesSummary of Product Characteristicsmedia_commonAgedgeneral practicePharmacologyAged 80 and overObserver VariationDrug pairbusiness.industryPharmacoepidemiologydrug information sources Drugdex drug–drug interaction general practice proton pump inhibitors Summary of Product CharacteristicsRegression analysisProton Pump InhibitorsDrug interactionMiddle Ageddrug information sources; Drugdex; drug-drug interaction; general practice; proton pump inhibitors; Summary of Product CharacteristicsSpontaneous reportingFamily medicineDrug Information ServicesInformation sourceFemalebusinessFamily Practicedrug-drug interactionBritish journal of clinical pharmacology
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